| Autor: |
Di Girolamo, Filippo G., Fiotti, Nicola, Sisto, Ugo G., Nunnari, Alessio, Colla, Stefano, Mearelli, Filippo, Vinci, Pierandrea, Schincariol, Paolo, Biolo, Gianni |
| Přispěvatelé: |
Di Girolamo, Filippo G., Fiotti, Nicola, Sisto, Ugo G., Nunnari, Alessio, Colla, Stefano, Mearelli, Filippo, Vinci, Pierandrea, Schincariol, Paolo, Biolo, Gianni |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Nutrition. 9 |
| ISSN: |
2296-861X |
| Popis: |
SARS-CoV-2 infection is often associated with severe inflammation, oxidative stress, hypoxia and impaired physical activity. These factors all together contribute to muscle wasting and fatigue. In addition, there is evidence of a direct SARS-CoV-2 viral infiltration into skeletal muscle. Aging is often characterized by sarcopenia or sarcopenic obesity These conditions are risk factors for severe acute COVID-19 and long-COVID-19 syndrome. From these observations we may predict a strong association between COVID-19 and decreased muscle mass and functions. While the relationship between physical inactivity, chronic inflammation, oxidative stress and muscle dysfunction is well-known, the effects on muscle mass of COVID-19-related hypoxemia are inadequately investigated. The aim of this review is to highlight metabolic, immunity-related and redox biomarkers potentially affected by reduced oxygen availability and/or muscle fatigue in order to shed light on the negative impact of COVID-19 on muscle mass and function. Possible countermeasures are also reviewed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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