Thromboelastometry in critically ill patients with disseminated intravascular coagulation
| Autor: | Nicole P. Juffermans, Joost C. M. Meijers, Jecko Thachil, David M. P. van Meenen, Marcella C.A. Müller |
|---|---|
| Přispěvatelé: | Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, Experimental Vascular Medicine, Vascular Medicine, AII - Inflammatory diseases, Graduate School, Anesthesiology |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Critical Illness Antithrombin III 030204 cardiovascular system & hematology Fibrinogen 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Coagulopathy Humans Platelet Blood Coagulation Aged Disseminated intravascular coagulation Receiver operating characteristic business.industry Antithrombin Hematology General Medicine Disseminated Intravascular Coagulation Middle Aged medicine.disease Thrombelastography Thromboelastometry Coagulation Cardiology Female business Biomarkers Protein C circulatory and respiratory physiology 030215 immunology medicine.drug |
| Zdroj: | Blood coagulation & fibrinolysis, 30(5), 181-187. Lippincott Williams and Wilkins |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/mbc.0000000000000808 |
| Popis: | Coagulopathy has a high incidence in critically ill patients and is often caused by disseminated intravascular coagulation (DIC). Although the clinical picture of DIC ranges from a prothrombotic state to severe consumption coagulopathy with an increased bleeding tendency, there are no clinical tests that reflect of in-vivo hemostatic profile. Rotational thromboelastometry (ROTEM) may be able to indicate whether a patient has a hypocoagulable or hypercoagulable profile and possibly be able to discriminate patients with and without DIC. The aim of this article was to study the diagnostic ability of thromboelastometry to detect DIC. A predefined subgroup analysis of a clinical trial in critically ill patients with a coagulopathy was done. ROTEM and markers of coagulation and levels of natural anticoagulants were measured in patients with and without DIC. Twenty-three patients were included, 13 fulfilled criteria for overt DIC. Patients with DIC had lower platelet count, lower levels of fibrinogen, factors II, VII and VIII compared with those without DIC. Antithrombin, protein C and S were also reduced in DIC patients. Receiver operator characteristic analyses showed that EXTEM CFT, alpha angle and MCF were capable of discriminating patients with and without DIC. Combination of ROTEM values with protein C or antithrombin further improved discriminatory ability. In patients with DIC, thromboelastometry profiles were more hypocoagulable compared with those without DIC. ROTEM correlates well with ISTH DIC score, diagnostic strength improves when ROTEM values are combined with antithrombin or protein C levels. Thereby, ROTEM may be a useful tool in diagnosing DIC in the critically ill. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|