IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination

Autor:	Yoshihito, Nihei, Monami, Kishi, Hitoshi, Suzuki, Ayako, Koizumi, Maiko, Yoshida, Sho, Hamaguchi, Masako, Iwasaki, Hiromitsu, Fukuda, Hisatsugu, Takahara, Masao, Kihara, Shigeki, Tomita, Yusuke, Suzuki
Rok vydání:	2022
Předmět:	Adult Vaccines Synthetic COVID-19 Vaccines Vaccination COVID-19 Glomerulonephritis IGA General Medicine Immunoglobulin A Internal Medicine Humans Female RNA Messenger mRNA Vaccines BNT162 Vaccine Hematuria
Zdroj:	Internal Medicine. 61:1033-1037
ISSN:	1349-7235 0918-2918
DOI:	10.2169/internalmedicine.8787-21
Popis:	A 28-year-old woman experienced gross hematuria after the administration of the second dose of an messenger ribonucleic acid (mRNA) vaccine (BNT162b2). She was diagnosed with Immunogloblin A nephropathy (IgAN) by a renal biopsy two weeks after vaccination, which revealed a mild increase in mesangial cells and a matrix with co-depositions of galactose-deficient IgA1 and C3 in the mesangial region. The gross hematuria and proteinuria gradually improved without any medication, suggesting that immune activation by the mRNA vaccine may not elicit continuous disease progression of IgAN. Thus, further studies investigating the relationship between mRNA vaccines against COVID-19 and the progression of IgAN should be conducted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2572145a43203173f07f14080abcbbb5 https://doi.org/10.2169/internalmedicine.8787-21 Zobrazit plný text záznamu