Aryl hydrocarbon receptor in mesenchymal stromal cells: new frontiers in AhR biology
Autor: | Kristopher K. Abney, Jacques Galipeau |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Inflammation Ligands Biochemistry Cell therapy 03 medical and health sciences Paracrine signalling 0302 clinical medicine medicine Basic Helix-Loop-Helix Transcription Factors Animals Humans Polycyclic Aromatic Hydrocarbons Receptor Molecular Biology Transcription factor biology Regeneration (biology) Mesenchymal stem cell Biphenyl Compounds Mesenchymal Stem Cells Cell Biology Aryl hydrocarbon receptor Shock Septic Cell biology 030104 developmental biology Receptors Aryl Hydrocarbon 030220 oncology & carcinogenesis biology.protein medicine.symptom Signal Transduction Transcription Factors |
Zdroj: | The FEBS journalReferences. 288(13) |
ISSN: | 1742-4658 |
Popis: | Mesenchymal stromal cells (MSCs) are non-hematopoietic cells that have been clinically explored as investigational cellular therapeutics for tissue injury regeneration and immune-mediated diseases. Their pharmaceutical properties arise from activation of endogenous receptors and transcription factors leading to a paracrine effect which mirror the biology of progenitors from which they arise. The aryl hydrocarbon receptor (AhR) is a transcription factor that has been extensively studied as an environmental sensor for xenobiotics, but recent findings suggest it can modulate immunological functions. Both genetic and pharmacological investigations revealed that MSCs express AhR and that it plays roles in inflammation, immunomodulation, and mesodermal plasticity of endogenous MSCs. Further, AhR has been shown to interact with key signaling cascades associated with these conditions. Therefore, AhR has potential to be an attractive target in both endogenous and culture-adapted MSCs for novel therapeutics to treat inflammation and other age-related disorders. |
Databáze: | OpenAIRE |
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