Cobalt-related interstitial lung disease or hard metal lung disease: A case series of Chinese workers
| Autor: | Xuqin Du, Jie Liu, Mulan Jin, Yiran Wang, Qiao Ye |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China Pathology medicine.medical_specialty Antineoplastic Agents Hormonal Prednisolone Health Toxicology and Mutagenesis Spontaneous remission Lithium Toxicology Tungsten 03 medical and health sciences 0302 clinical medicine Occupational Exposure medicine Humans 030212 general & internal medicine Exertion Hard metal Lung Inhalation business.industry Public Health Environmental and Occupational Health Occupational dust exposure Interstitial lung disease Dust Cobalt Middle Aged medicine.disease respiratory tract diseases Treatment Outcome medicine.anatomical_structure 030228 respiratory system Giant cell Particulate Matter Lung Diseases Interstitial business |
| Zdroj: | Toxicology and Industrial Health. 37:280-288 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/07482337211000989 |
| Popis: | Hard metal lung disease (HMLD) is rarely diagnosed and is caused by the occupational inhalation of hard metal dust, mainly cobalt. The diagnosis of HMLD is based on a thorough occupational dust exposure combined with clinical–radiological–histological findings. We present a series of four Chinese workers who had occupational exposure to cobalt acid lithium or cobalt and tungsten dust. Four patients all complained of intermittent cough, chest tightness, or shortness of breath on exertion. High-resolution computed tomography scans presented bilateral ground-glass attenuation, consolidations, and/or reticular opacities with diffuse small nodules. Histologic findings showed that interstitial inflammation and fibrotic lesions distributed peribronchioles. The infiltrations by macrophages as well as visible multinucleated giant cells indicated giant cell interstitial pneumonia (GIP). Cobalt was detectable in the lung tissues of two patients measured by inductively-coupled plasma mass spectrometry. The first patient was diagnosed with cobalt-related interstitial lung disease (ILD), while the others were HMLD. GIP is the classic pathology of cobalt-related ILD or HMLD. One of the patients showed spontaneous remission after the cessation of exposure, while the other three recovered within 6–32 weeks after avoiding occupational exposure and using corticosteroids. At follow-up, all four patients showed no recurrence. A multidisciplinary diagnostic panel including occupational cobalt exposure evaluation is beneficial to recognize cobalt-related ILD or HMLD and to indicate the necessity of prevention. |
| Databáze: | OpenAIRE |
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