SUPPLEMENTARY FIGURE 2. SSTN inhibition of IGF1R in myeloma inhibits adhesion-independent cell survival. from Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth
| Autor: | Alan C. Rapraeger, Ralph D. Sanderson, Yang Yang, Oisun Jung, DeannaLee M. Beauvais |
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| Rok vydání: | 2023 |
| DOI: | 10.1158/0008-5472.22411512 |
| Popis: | A. CAG cells are plated for 2 hr on VN or FN in the presence or absence of 10 μg/mL VLA-4 (P1H4) or 30 μg/mL αvβ5 (P1F6) integrin blocking antibodies; B. CAG myeloma cells grown for 72 hr in the presence of 10 μg/mL VLA-4 (P1H4) or 30 μg/mL αvβ5 (P1F6) integrin blocking antibodies, 10 μM AG538, or 30 μM SSTNIGF1R are quantified and graphed relative to no treatment (set to 1.0). Error bars = SEM. |
| Databáze: | OpenAIRE |
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