Auto‐inflammation and auto‐immunity pathways are associated with emergence of BOS in pediatric lung transplantation

Autor: Carol K. Conrad, Haley Hedlin, Hyunsook Chin, Don Hayes, Peter S. Heeger, Albert Faro, Samuel Goldfarb, Ernestina Melicoff‐Portillo, Mohanakumar Thalachallour, Jonah Odim, Marc Schecter, Gregory A. Storch, Gary A. Visner, Nikki M. Williams, Karen Kesler, Lara Danziger‐Isakov, Stuart C. Sweet
Rok vydání: 2022
Předmět:
Zdroj: Pediatr Transplant
ISSN: 1399-3046
1397-3142
DOI: 10.1111/petr.14247
Popis: BACKGROUND. Long-term survival after lung transplantation (LTx) is limited by chronic lung allograft dysfunction (CLAD). Methods. We report an analysis of cytokine profiles in bronchoalveolar lavage samples collected during a prospective multicenter non-interventional trial primarily designed to determine the impact of community-acquired respiratory viral infections (CARV) in outcomes after pediatric LTx. In this analysis, we identify potential biomarkers of auto-inflammation and auto-immunity associated with survival and risk of bronchiolitis obliterans (BOS) after LTx with cytokine analysis of bronchoalveolar lavage fluid (BALF) from 61 pediatric recipients. RESULTS. Higher IL23 (p=0.048) and IL31 (p=0.035) levels were associated with the risk of BOS, and lower levels of epithelial growth factor (EGF) (p=0.041) and eotaxin (EOX) (p=0.017) were associated with BOS. Analysis using conditional inference trees to evaluate cytokines at each visit associated with survival identified soluble CD30 (p
Databáze: OpenAIRE
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