Simultaneous dual-isotope imaging based on an artificial neural network for evaluating myocardial perfusion and fatty acid metabolism
| Autor: | Atsushi Kubo, Koichi Ogawa, Jingming Bai, Yutaka Imai, Jun Hashimoto |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Technetium Tc 99m Sestamibi Myocardial Infarction Perfusion scanning Pentadecanoic acid Imaging phantom chemistry.chemical_compound medicine Humans Radiology Nuclear Medicine and imaging Myocardial infarction Aged Aged 80 and over Tomography Emission-Computed Single-Photon Photons medicine.diagnostic_test Fatty acid metabolism Artificial neural network business.industry Iodobenzenes Phantoms Imaging Fatty Acids Myocardial Perfusion Imaging Middle Aged medicine.disease chemistry Radiographic Image Interpretation Computer-Assisted Female Neural Networks Computer Radiopharmaceuticals Cardiology and Cardiovascular Medicine business Nuclear medicine Perfusion Monte Carlo Method Emission computed tomography |
| Zdroj: | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 20(3) |
| ISSN: | 1532-6551 |
| Popis: | We contrived a scatter correction method based on an artificial neural network (ANN) and applied it to the simultaneous evaluation of myocardial perfusion and fatty acid metabolism in single-photon emission computed tomography (SPECT).The count data of three energy windows were used as inputs of the ANN. The count ratios of the estimated primary-to-total photons for (99m)Tc and (123)I, which were used to reconstruct (99m)Tc and (123)I images, were calculated using the ANN. In a phantom study, single- and dual-isotope imaging with (99m)Tc/(123)I and (201)Tl/(123)I was performed by means of a cardiac phantom simulating patients with and without obesity. In a human study, five normal volunteers and ten patients with myocardial infarction underwent myocardial perfusion and fatty acid metabolism imaging with single and dual SPECT with combinations of (99m)Tc-methoxyisobutylisonitrile/(123)I-beta-methyl(p-iodophenyl)pentadecanoic acid (BMIPP) and (201)Tl/(123)I-BMIPP as tracers.Technetium-99m yielded more homogeneous images than (201)Tl because of the lower degree of photon attenuation, especially in the condition of obese patients, resulting in clearer visualization of the perfusion-metabolism mismatch. Dual (99m)Tc/(123)I SPECT offered comparable images with single SPECT in assessing myocardial damage.The method effectively separated (99m)Tc and (123)I primary photons and proved applicable to (99m)Tc/(123)I dual-isotope myocardial SPECT. |
| Databáze: | OpenAIRE |
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