Could be considered serum anti-S-100 autoantibodies a biomarker in patients with acute non-cardioembolic ischemic stroke?
| Autor: | Manole Cojocaru, Violeta Sapira, Bucharest Pharmacy, Daniela Stefanescu, Inimioara Mihaela Cojocaru |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Romanian Medical Journal, Vol 65, Iss 1, Pp 60-64 (2018) |
| ISSN: | 2069-606X 1220-5478 |
| Popis: | In ischemic stroke patients there were found autoantibodies against brain epitopes. The presence of anti-S-100 autoantibodies may reflect alteration and dysfunction of the blood-brain barrier. The aim of the study was to assess the prevalence of serum anti-S-100 autoantibodies in the early stage of ischemic non-cardioembolic stroke and their correlation with clinical outcome. The study included 78 patients with acute non-cardioembolic ischemic stroke, 46 females and 32 males, ranges from 46 to 81 years, mean age 74.3±6.8 years. Blood samples for anti-S-100 autoantibodies measurement were taken within 24 hours after the onset of ischemic stroke. Seventy-two patients served as matched controls 43 females and 29 males, ranges from 42 to 79 years, mean age 71.3±6.4 years. Serum anti-S-100 autoantibodies were measured by means of ELISA. Significance difference between groups was calculated by the Wilcoxon signed rank method. A value of p |
| Databáze: | OpenAIRE |
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