The WHO recommendation of home fortification of foods with multiple-micronutrient powders in children under 2 years of age and its effectiveness on anaemia and weight: a pragmatic cluster-randomized controlled trial
| Autor: | Ildephonse Ngabonziza, Mamadou Konaté, Mamadou Alpha Diallo, Philippe Donnen, Ousmane Touré, Boncana Traoré, Michèle Dramaix, Yassinmè Elysée Somassè |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pediatrics medicine.medical_specialty Anemia Medicine (miscellaneous) Intervention group Mali Disease cluster law.invention Hemoglobins 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Prevalence medicine Humans Micronutrients 030212 general & internal medicine 030109 nutrition & dietetics Nutrition and Dietetics business.industry Body Weight Public Health Environmental and Occupational Health Infant Micronutrient medicine.disease Research Papers Standard error Dietary Supplements Food Fortified Home fortification Female business Severe anaemia |
| Zdroj: | Public Health Nutr |
| ISSN: | 1475-2727 1368-9800 |
| Popis: | ObjectiveTo assess under real community settings the effectiveness of the WHO strategy of home fortification of foods (HFF) with multiple-micronutrient powders on Hb change, anaemia and weight in children.DesignA pragmatic cluster-randomized controlled trial.SettingForty villages in the Nioro Circle in Mali and 722 children aged 6–23 months were randomized to the intervention or control group. The intervention consisted of a daily dose of multiple-micronutrient powder for 3 months; in the control group, no supplement was given. In both groups, mothers received group education on child complementary feeding. Changes in weight, Hb concentration and anaemia were assessed as primary outcomes at baseline and 3 months. The HFF effect was determined using regression analyses and quantile regression with standard errors taking account of the cluster design.SubjectsChildren aged 6–23 months.ResultsOverall prevalence of anaemia in the sample was high: 90 %. HFF provided a modest but statistically significant Hb changev. no intervention (0·50v. 0·09 g/dl,P=0·023). Prevalence of anaemia changed little: 91·3–85·8 % (P=0·04) in the intervention groupv. 88·1–87·5 % % (P=0·86) in the control group. Proportion of severe anaemia was reduced by 84 % (from 9·8 to 1·6 %) in the intervention group, but increased in the control group (from 8·5 to 10·8 %). No effect was observed on weight.ConclusionsThe WHO HFF strategy to fight anaemia showed a modest change on Hb concentration and significantly reduced the rate of severe anaemia. |
| Databáze: | OpenAIRE |
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