Antibacterial Cyclic Tripeptides from Antarctica-Sponge-Derived Fungus Aspergillus insulicola HDN151418
| Autor: | Guojian Zhang, Chunxiao Sun, Zilin Ren, Huan Zhou, Ziping Zhang, Qian Che, Yaxin Han, Liu Yu, Mudassir Shah, Tianjiao Zhu, Dehai Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cell Survival
Protein Conformation Stereochemistry Bacillus cereus Ethyl acetate Antarctic Regions Pharmaceutical Science Antineoplastic Agents Tripeptide Bacillus subtilis 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound cyclic tripeptides antibacterial Antarctica sponge-derived fungus Aspergillus insulicola Cell Line Tumor Drug Discovery Animals Humans Aspergillus insulicola Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 Mycobacterium phlei 030304 developmental biology 0303 health sciences Bacteria biology 010405 organic chemistry fungi Edwardsiella tarda Absolute configuration Antarctica sponge-derived fungus biology.organism_classification Antimicrobial Anti-Bacterial Agents Porifera 0104 chemical sciences antibacterial Aspergillus chemistry lcsh:Biology (General) cyclic tripeptides Peptides |
| Zdroj: | Marine Drugs, Vol 18, Iss 532, p 532 (2020) Marine Drugs Volume 18 Issue 11 |
| ISSN: | 1660-3397 |
| Popis: | Three new aspochracin-type cyclic tripeptides, sclerotiotides M–O (1–3), together with three known analogues, sclerotiotide L (4), sclerotiotide F (5), and sclerotiotide B (6), were obtained from the ethyl acetate extract of the fungus Aspergillus insulicola HDN151418, which was isolated from an unidentified Antarctica sponge. Spectroscopic and chemical approaches were used to elucidate their structures. The absolute configuration of the side chain in compound 4 was elucidated for the first time. Compounds 1 and 2 showed broad antimicrobial activity against a panel of pathogenic strains, including Bacillus cereus, Proteus species, Mycobacterium phlei, Bacillus subtilis, Vibrio parahemolyticus, Edwardsiella tarda, MRCNS, and MRSA, with MIC values ranging from 1.56 to 25.0 µM. |
| Databáze: | OpenAIRE |
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