Antihypertensive medication-taking. Investigation of a simple regimen
| Autor: | D, Guerrero, P, Rudd, C, Bryant-Kosling, B, Middleton, B ], Middleton BF [corrected to Middleton |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty business.industry Vial Surgery Regimen Clinical Protocols Double-Blind Method Research Design Pill Internal medicine Ambulatory Hypertension Internal Medicine medicine Drug Evaluation Humans Patient Compliance Female Isradipine Medical prescription business Short duration Antihypertensive medication |
| Zdroj: | American journal of hypertension. 6(7 Pt 1) |
| ISSN: | 0895-7061 |
| Popis: | In search of strategies to improve compliance, we assessed medication-taking behavior among 19 ambulatory hypertensives, using both pill counts and electronic monitoring. The regimen consisted of one pill each day foror = 63 weeks with return visits at 1 to 4 week intervals. The study population was 79% male, 68% white, and 16% black with mean (+/- SEM) age 58.4 +/- 2.5 years. Only 51% of the intervisit intervals displayedor = 80% of vial openings within the desirable range (24 +/- 6 h). Pill counts detected only 2% of suboptimal interdosing intervals identified by electronic monitoring. Early changes in compliance correlated well with later changes (r = 0.83, P = .002). A few of the subjects exhibited a large deviation from the prescription, uncorrectable with drugs having a long duration of action. We conclude that (a) pill counts tend to overestimate patients' compliance rates; (b) changes in medication-taking behavior early in therapy may predict subsequent compliance rates; and (c) prolonging drug action may compensate for some imperfect medication-taking behavior. |
| Databáze: | OpenAIRE |
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