Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study

Autor: Luz Maria Medrano, Eduardo Tamayo, María Ángeles Jiménez-Sousa, Lucia Rico, Esther Gómez-Sánchez, Pilar Liu, Mario Lorenzo, Amanda Fernández-Rodríguez, Alejandra Fadrique, Salvador Resino, Raquel Almansa
Přispěvatelé: Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Junta de Castilla y León (España)
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Lipopolysaccharide Receptors
lcsh:Medicine
Gastroenterology
0302 clinical medicine
Gene Frequency
3213.01 Cirugía Abdominal
Risk Factors
Septic shock
Genotype
lcsh:Science
Multidisciplinary
Hazard ratio
Middle Aged
Shock
Septic
Choque séptico
Female
medicine.medical_specialty
European Continental Ancestry Group
Polymorphism
Single Nucleotide
White People
Article
Sepsis
03 medical and health sciences
Internal medicine
medicine
Humans
Polymorphism
Mortality
Cardiac Surgical Procedures
Allele frequency
Alleles
Polimorfismo
Aged
Retrospective Studies
3213.07 Cirugía del Corazón
business.industry
lcsh:R
Case-control study
030208 emergency & critical care medicine
Retrospective cohort study
medicine.disease
030104 developmental biology
Case-Control Studies
Mortalidad
lcsh:Q
business
Abdominal surgery
Zdroj: Repisalud
Instituto de Salud Carlos III (ISCIII)
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
UVaDOC: Repositorio Documental de la Universidad de Valladolid
Universidad de Valladolid
Scientific Reports
UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname
ISSN: 2045-2322
DOI: 10.1038/s41598-018-20766-7
Popis: Producción Científica
The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience’s MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.
Centro Nacional de Genotipado (grant CEGEN-PRB2-ISCIII)
Instituto de Salud Carlos III (grants PT13/0001, PI15/01451, CD13/00013, CD14/00002 and CP14CIII/00010)
Junta de Castilla y Leon (grants GR463/A/10 and GR773/A/13)
PFIZER (grant CT25-ESP01-01)
Databáze: OpenAIRE
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