Reticulon protein-1C is a key component of MAMs
| Autor: | Bisan Mehdawy, Mauro Piacentini, Giuseppe Filomeni, Valentina Reali, Claudia Marsella, Federica Di Sano, Anna Risuglia, Gian Maria Fimia, Manuela Antonioli, Roberta Nardacci, Federica Rossin |
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| Přispěvatelé: | Reali, Valentina, Mehdawy, Bisan, Nardacci, Roberta, Filomeni, Giuseppe, Risuglia, Anna, Rossin, Federica, Antonioli, Manuela, Marsella, Claudia, Fimia, Gian Maria, Piacentini, Mauro, Di Sano, Federica |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Settore BIO/06 Cellular homeostasis Nerve Tissue Proteins Mitochondrion Biology Inbred C57BL Small Interfering Endoplasmic Reticulum Mitochondrial Dynamics 03 medical and health sciences Mice 0302 clinical medicine RTN-1C Organelle Tumor Cells Cultured Animals Humans Calcium Signaling RNA Small Interfering Molecular Biology 030304 developmental biology Calcium signaling endoplasmic reticulum MAM mitochondria 0303 health sciences Cultured Animal Endoplasmic reticulum Cell Biology Membrane contact site Cell biology Tumor Cells Mitochondria Mitochondrial Dynamic Mice Inbred C57BL Crosstalk (biology) Reticulon Gene Knockdown Techniques Mitochondrial Membranes Gene Knockdown Technique Nerve Tissue Protein RNA Mitochondrial Membrane Protein Binding 030217 neurology & neurosurgery Human |
| Popis: | The endoplasmic reticulum (ER) is a key organelle fundamental for the maintenance of cellular homeostasis and the determination of cell fate under stress conditions. Reticulon-1C (RTN-1C) is a member of the reticulon family proteins localized primarily on the ER membrane and known to regulate ER structure and function. Several cellular processes depend on the structural and functional crosstalk between different organelles, particularly on the endoplasmic reticulum and mitochondria. These dynamic contacts, called mitochondria-associated ER membranes (MAMs), are essential for the maintenance of mitochondrial structure and participate in lipid and calcium exchanges between the two organelles.In this study we investigated the impact of RTN-1C modulation on mitochondrial dynamics. We demonstrate that RTN-1C controls mitochondrial structure and function affecting intracellular Ca2+ homeostasis and lipid exchange between ER and mitochondria. We propose that these events depend on RTN-1C involvement in the regulation of ER–mitochondria cross-talk and define a role for RTN-1C in maintaining the function of contacts between the two organelles. |
| Databáze: | OpenAIRE |
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