Efficacy, duration, and onset of immunogenicity of a West Nile virus vaccine, live Flavivirus chimera, in horses with a clinical disease challenge model
| Autor: | K. K. Seino, R. A. Bowen, Shuhua Zhang, P. P. Humphrey, E. P. J. Gibbs, M. W. Mellencamp, Sarah E. Beachboard, Maureen T. Long |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Time Factors viruses Dose-Response Relationship Immunologic Antibodies Viral Vaccines Attenuated Severity of Illness Index Random Allocation Immune system Immunity Animals Medicine Flavivirus Infections Horses Viremia West Nile Virus Vaccines Virulence biology Chimera business.industry Immunogenicity virus diseases General Medicine biology.organism_classification medicine.disease Virology Vaccination Flavivirus Treatment Outcome Immunology biology.protein Female Horse Diseases Safety Antibody business West Nile virus West Nile Fever Encephalitis |
| Zdroj: | Equine Veterinary Journal. 39:491-497 |
| ISSN: | 0425-1644 |
| DOI: | 10.2746/042516407x217416 |
| Popis: | Summary Reasons for performing study: West Nile virus (WNF) is a Flavivirus responsible for a life-threatening neurological disease in man and horses. Development of improved vaccines against Flavivirus infections is therefore important. Objectives: To establish that a single immunogenicity dose of live Flavivirus chimera (WN-FV) vaccine protects horses from the disease and it induces a protective immune response, and to determine the duration of the protective immunity. Methods: Clinical signs were compared between vaccinated (VACC) and control (CTRL) horses after an intrathecal WNV challenge given at 10 or 28 days, or 12 months post vaccination. Results: Challenge of horses in the immunogenicity study at Day 28 post vaccination resulted in severe clinical signs of WNV infection in 10/10 control (CTRL) compared to 1/20 vaccinated (VACC) horses (P |
| Databáze: | OpenAIRE |
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