Biochemical markers in screening for preeclampsia and intrauterine growth restriction
| Autor: | Krzysztof Szaflik, Magdalena Litwińska, Przemysław Oszukowski, Piotr Kaczmarek, Waldemar Litwiński, Maciej Korcz, Ewelina Litwińska |
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| Rok vydání: | 2015 |
| Předmět: |
Placental growth factor
medicine.medical_specialty Pregnancy-associated plasma protein A Intrauterine growth restriction Preeclampsia Pre-Eclampsia Interquartile range Pregnancy medicine Humans Pregnancy-Associated Plasma Protein-A Chorionic Gonadotropin beta Subunit Human reproductive and urinary physiology Gynecology Fetal Growth Retardation business.industry Obstetrics Multiple of the median Obstetrics and Gynecology medicine.disease PIGF Case-Control Studies Gestation Female business Biomarkers |
| Zdroj: | Ginekologia polska. 86(8) |
| ISSN: | 0017-0011 |
| Popis: | Objectives The aim of the study was to evaluate the relationship between the concentrations of substances released by the placenta: placental growth factor (PIGF), pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (beta-hCG) and the risk of early and late preeclampsia (PE) and intrauterine fetal growth restriction (IUGR). Material and methods A total of 180 pregnant women between 11+0 and 13+6 weeks gestation were recruited for a case-control study Twenty-two patients suffered from early PE, 29 patients from late PE. Data analyzed during the study included maternal histoty and concentrations of PAPP-A, PlGF beta-hCG. Results The multiple of the median (MoM) value of the PAPP-A concentrations was 1.01 in the control group (interquartile range (1QR), 0.65-1.55), 0.67 (1QR, 0.382-0.82) in the group of patients with early preeclampsia and 0.74 (IQ, 0.33-1.09) in the group of patients suffering from late preeclampsia. MoM value of the PIGF concentrations was 1.21 in the control group (IQR, 0.93-1.57), 0.62 (IQR, 0.51-0.96) in the group of patients with early preeclampsia and 0.92 (lQR, 0.63-1.09) in the group of patients suffering from late preeclampsia. MoM value of beta-hCG concentrations was 1.14 in the control group (IQR, 0.75-1.49), 1.08(IQR, 0.74-1.23) in the group of patients with early preeclampsia and 1,25(IQR, 1,05-1,49) in the group of patients suffering from late preeclampsia. The performance of screening was determined by the areas under the curve and detection rates, with a fixed false-positive rate of 10%. Conclusions Decreased levels of PAPP-A and PIGF are related to an increased risk of preeclampsia and its complications. |
| Databáze: | OpenAIRE |
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