Influence of angiotensin II on the concentration of arterial plasma electrolytes in anaesthetized sheep
| Autor: | P. L. Sugden, I. D. Chapman, E. C. Osborn, S. Howes, J. C. Mackenzie, D. M. Aitken, J. Wilson, G. V. Rigby, O. F. Mason |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Epinephrine Endocrinology Diabetes and Metabolism Potassium Sodium chemistry.chemical_element Blood Pressure Electrolyte Tachyphylaxis Chloride Electrolytes Norepinephrine Endocrinology Chlorides Internal medicine medicine Animals Sheep Dose-Response Relationship Drug Arterial plasma Angiotensin II Blood pressure chemistry Calcium Female Angiotensin I medicine.drug |
| Zdroj: | The Journal of endocrinology. 104(1) |
| ISSN: | 0022-0795 |
| Popis: | Angiotensin II and I significantly raised potassium and lowered sodium and chloride ion concentrations in arterial plasma, with peak changes occurring in the first 2 min of a 6-min infusion period. The octapeptide increased the arterial K+ level in a dose-dependent manner, but the response showed tachyphylaxis when multiple infusions of 6-min duration were administered after a recovery interval of only 5 min. Raising the arterial blood pressure by 20–33 mmHg with adrenaline and noradrenaline failed to account for the increase in arterial plasma K+ concentration produced by the two peptides. These findings, in particular the rise in K+ concentration, are discussed in relation to possible mechanisms by which angiotensin II affects arteriolar tone. J. Endocr. (1985) 104, 143–148 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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