Allergic bronchopulmonary aspergillosis in pediatric practice
| Autor: | Roy Patterson, Richard A. Mintzer, Mary Roberts, Josephine L. F. Wang, Michael Rosenberg |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Immunoglobulins Atelectasis Aspergillosis Immunoglobulin E Gastroenterology Aspergillus fumigatus Recurrence Prednisone Internal medicine Humans Medicine Child Bronchiectasis biology Bronchography business.industry Aspergillosis Allergic Bronchopulmonary biology.organism_classification medicine.disease Pediatrics Perinatology and Child Health Immunology biology.protein Female Allergic bronchopulmonary aspergillosis business medicine.drug |
| Zdroj: | The Journal of Pediatrics. 94:376-381 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(79)80574-0 |
| Popis: | Twelve cases of allergic bronchopulmonary aspergillosis in the pediatric age group are reported. The average age of diagnosis was 14.5 years with a range from 6 to 18 years. All patients had a history of pulmonary infiltrations or atelectasis or both documented by chest radiographs. Eight patients had bronchograms or tomograms, and seven of them showed proximal bronchiectasis. Total serum IgE concentrations were elevated in all patients. Precipitating antibodies against Aspergillus fumigatus were positive in all patients at the time of diagnosis, and became negative in some after therapy. The specific IgE or IgG antibody activity against Af was elevated in all 12 patients. After prednisone was started the total serum IgE sharply declined to a plateau and remained at this level until a flare of allergic aspergillosis occurred. A flare of allergic aspergillosis is characterized by an increasing total serum IgE concentration followed by pulmonary infiltration. Clinical and roentgenologic improvements were observed after steroid therapy. The importance and methods of early diagnosis in the pediatric population are discussed. |
| Databáze: | OpenAIRE |
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