Liver transplantation for adenomatosis: European experience

Autor: Christophe Laurent, Yves Patrice Le-Treut, Jorge Ortiz-de-Urbina, François-René Pruvot, Martin Oliverius, Jean Gugenheim, Phillipe Bachelier, Ephrem Salamé, Anaelle David, Vincenzo Scuderi, Jürgen Klempnauer, René Adam, Stefano Di-Sandro, Paulette Bioulac-Sage, Jan Lerut, Jean Yves Mabrut, Francis Navarro, Jeroˆme Dumortier, Eric Vibert, Marco Spada, Roberto Troisi, Michele Colledan, Ignacio Gonzalez-Pinto, Laurence Chiche, V. Vincenzo Mazzafero, Bertrand Suc
Přispěvatelé: Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Centre hépato-biliaire (CHB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Chirurgie Générale et Digestive [Rangueil], CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], CHU Strasbourg, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire de Nice (CHU Nice), Hôpital de la Croix-Rousse [CHU - HCL], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Physiopathologie du cancer du foie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pathologie [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Chiche, L, David, A, Adam, R, Oliverius, M, Klempnauer, J, Vibert, E, Colledan, M, Lerut, J, Mazzafero, V, Di-Sandro, S, Laurent, C, Scuderi, V, Suc, B, Troisi, R, Bachelier, P, Dumortier, J, Gugenheim, J, Mabrut, J, Gonzalez-Pinto, I, Pruvot, F, Le-Treut, Y, Navarro, F, Ortiz-De-Urbina, J, Salame, E, Spada, M, Bioulac-Sage, P
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Registrie
Adult
Male
medicine.medical_specialty
Carcinoma
Hepatocellular
medicine.medical_treatment
Clinical Decision-Making
[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery
Glycogen Storage Disease Type I
Liver transplantation
Gastroenterology
Adenoma
Liver Cell
Cohort Studies
03 medical and health sciences
Rare Diseases
0302 clinical medicine
Rare Disease
Retrospective Studie
Internal medicine
Carcinoma
Humans
Medicine
Registries
Retrospective Studies
Transplantation
Glycogen storage disease type I
Hepatology
business.industry
Liver Neoplasms
Focal nodular hyperplasia
Retrospective cohort study
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Hepatocellular adenoma
medicine.disease
Liver Transplantation
3. Good health
Europe
Treatment Outcome
Liver Neoplasm
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Female
030211 gastroenterology & hepatology
Surgery
Cohort Studie
business
Human
Zdroj: Liver Transplantation
Liver Transplantation, Wiley, 2016, 22 (4), pp.516-526. ⟨10.1002/lt.24417⟩
ISSN: 1527-6465
1527-6473
DOI: 10.1002/lt.24417⟩
Popis: International audience; The aim of this study was to collect data from patients who underwent liver transplantation (LT) for adenomatosis; to analyze the symptoms, the characteristics of the disease, and the recipient outcomes; and to better define the role of LT in this rare indication. This retrospective multicenter study, based on data from the European Liver Transplant Registry, encompassed patients who underwent LT for adenomatosis between January 1, 1986, and July 15, 2013, in Europe. Patients with glycogen storage disease (GSD) type IA were not excluded. This study included 49 patients. Sixteen patients had GSD, and 7 had liver vascular abnormalities. The main indications for transplantation were either a suspicion of hepatocellular carcinoma (HCC; 15 patients) or a histologically proven HCC (16 patients), but only 17 had actual malignant transformation (MT) of adenomas. GSD status was similar for the 2 groups, except for age and the presence of HCC on explants (P = 0.030). Three patients with HCC on explant developed recurrence after transplantation. We obtained and studied the pathomolecular characteristics for 23 patients. In conclusion, LT should remain an extremely rare treatment for adenomatosis. Indications for transplantation primarily concern the MT of adenomas. The decision should rely on morphological data and histological evidence of MT. Additional indications should be discussed on a case-by-case basis. In this report, we propose a simplified approach to this decision-making process.
Databáze: OpenAIRE
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