Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
| Autor: | Barend Mees, Jan H.M. Tordoir, Sjeng Quicken, Wouter Huberts, Yeshi de Bruin, Tammo Delhaas |
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| Přispěvatelé: | RS: Carim - H07 Cardiovascular System Dynamics, RS: Carim - Heart, Biomedische Technologie, RS: Carim - V03 Regenerative and reconstructive medicine vascular disease, MUMC+: MA Med Staf Spec Vaatchirurgie (9), Vascular Surgery, MUMC+: MA Vaatchirurgie CVC (3), Biomedical Engineering, Cardiovascular Biomechanics |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Polyurethane
HEMODIALYSIS Materials science medicine.medical_treatment FLOW Polyurethanes EARLY EXPERIENCE 030232 urology & nephrology Material choice MISMATCH Hemodynamics 030204 cardiovascular system & hematology Anastomosis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Renal Dialysis Shear stress medicine Pressure VASCULAR ACCESS Humans Computer Simulation ANASTOMOSES Vein Dialysis graft Dialysis Neointimal hyperplasia Original Paper Mechanical Engineering medicine.disease Biomechanical Phenomena Compliance (physiology) MODEL medicine.anatomical_structure chemistry Fluid structure interaction modelling Modeling and Simulation SIMULATION Stress Mechanical Blood Flow Velocity Biotechnology Biomedical engineering |
| Zdroj: | Biomechanics and modeling in mechanobiology, 19(2), 713-722. Springer Biomechanics and Modeling in Mechanobiology Biomechanics and Modeling in Mechanobiology, 19(2), 713-722. Springer |
| ISSN: | 1617-7940 1617-7959 |
| Popis: | Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear ($$\hbox {OSI} >0.25$$OSI>0.25) and very high wall shear stress ($$>40 \hbox { Pa}$$>40Pa) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts. |
| Databáze: | OpenAIRE |
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