In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes
| Autor: | Andrew Murison, Andrew Erlandsen, Padma Raman-Caplan, Heather Zwickey, Kimberly A. Brown, Jeremy Mikolai, William L. Gregory |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
CD3 Receptor expression T-Lymphocytes chemical and pharmacologic phenomena Pharmacology Withania somnifera Withania Lymphocyte Activation Immune system Antigen Antigens CD Medicine Humans Receptor biology business.industry Plant Extracts biology.organism_classification Killer Cells Natural Complementary and alternative medicine Immunology biology.protein business CD8 |
| Zdroj: | Journal of alternative and complementary medicine (New York, N.Y.). 15(4) |
| ISSN: | 1557-7708 |
| Popis: | Objective: This study investigated the immunologic effects of Ashwagandha (Withania somnifera) on four types of immune cells in a human sample to determine the immunologic mechanism. Design: Five (5) participants consumed 6 mL of an Ashwagandha root extract twice daily for 96 hours. Ashwagandha was administered with anupana (whole milk). Peripheral blood samples were collected at 0, 24, and 96 hours and compared for differences in cell surface expression of CD4, CD8, CD19, CD56, and CD69 receptors by flow cytometry. Results: Significant increases were observed in the expression of CD4 on CD3+ T cells after 96 hours. CD56+ NK cells were also activated after 96 hours as evidenced by expression of the CD69 receptor. At 96 hours of use, mean values of receptor expression for all measured receptor types were increased over baseline, indicating that a major change in immune cell activation occurred across the sample. Conclusions: Effects on immune cell activation with use of Ashwagandha warrant further... |
| Databáze: | OpenAIRE |
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