An In Vitro Study of Antibacterial Properties of Electrospun Hypericum perforatum Oil-Loaded Poly(lactic Acid) Nonwovens for Potential Biomedical Applications
| Autor: | Beata Gutarowska, Anna Bednarowicz, Dominik Sikorski, Zbigniew Draczyński, Dawid Stawski, Sławomir Sztajnowski, Cesar Hernández, Ayben Pakolpakçıl, Nina Tarzynska, Justyna Szulc, Izabella Krucińska |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Technology
Hypericum perforatum oil Nonwoven fabric QH301-705.5 QC1-999 Population chemistry.chemical_compound Tissue engineering General Materials Science Biology (General) education QD1-999 Instrumentation electrospinning Fluid Flow and Transfer Processes education.field_of_study Physics Process Chemistry and Technology technology industry and agriculture General Engineering Engineering (General). Civil engineering (General) Antimicrobial Biodegradable polymer Electrospinning Computer Science Applications Lactic acid Chemistry antibacterial chemistry Chemical engineering biodegradable poly(lactic acid) TA1-2040 Antibacterial activity |
| Zdroj: | Applied Sciences Volume 11 Issue 17 Applied Sciences, Vol 11, Iss 8219, p 8219 (2021) |
| ISSN: | 2076-3417 |
| Popis: | The growth of population and increase in diseases that cause an enormous demand for biomedical material consumption is a pointer to the pressing need to develop new sustainable biomaterials. Electrospun materials derived from green polymers have gained popularity in recent years for biomedical applications such as tissue engineering, wound dressings, and drug delivery. Among the various bioengineering materials used in the synthesis of a biodegradable polymer, poly(lactic acid) (PLA) has received the most attention from researchers. Hypericum perforatum oil (HPO) has antimicrobial activity against a variety of bacteria. This study aimed to investigate the development of an antibacterial sustainable material based on PLA by incorporating HPO via a simple, low-cost electrospinning method. Chemical, morphological, thermal, thickness and, air permeability properties, and in vitro antibacterial activity of the electrospun nonwoven fabric were investigated. Scanning electron microscopy (SEM) was used to examine the morphology of the electrospun nonwoven fabric, which had bead-free morphology ultrafine fibers. Antibacterial tests revealed that the Hypericum perforatum oil-loaded poly(lactic acid) nonwoven fabrics obtained had high antibacterial efficiency against Escherichia coli and Staphylococcus aureus, indicating a strong potential for use in biomedical applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|