Preparation, characterization and in-vivo evaluation of microemulsions containing tamoxifen citrate anti-cancer drug
| Autor: | Mahmoud Ebrahimi, Mohammad Karimi, Amir Biriaee, Shiva Golmohammadzadeh, Faranak Dehghani, Nafiseh Farhadian |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Chemistry Pharmaceutical media_common.quotation_subject Drug Evaluation Preclinical Pharmaceutical Science Antineoplastic Agents Nanoconjugates 02 engineering and technology 030226 pharmacology & pharmacy Mice 03 medical and health sciences 0302 clinical medicine Pulmonary surfactant In vivo Animals Microemulsion Spinal Cord Neoplasms Solubility media_common Drug Carriers Mice Inbred BALB C Chromatography Chemistry 021001 nanoscience & nanotechnology Tumor Burden Bioavailability Tamoxifen Tamoxifen Citrate Emulsions Female Nanocarriers 0210 nano-technology |
| Zdroj: | European Journal of Pharmaceutical Sciences. 96:479-489 |
| ISSN: | 0928-0987 |
| Popis: | The aim of this study was to prepare and characterize a new nanocarrier for oral delivery of tamoxifen citrate (TMC) as a lipophilic oral administrated drug. This drug has low oral bioavailability due to its low aqueous solubility. To enhance the solubility of this drug, the microemulsion system was applied in form of oil-in-water. Sesame oil and Tween 80 were used as drug solvent oil and surfactant, respectively. Two different formulations were prepared for this purpose. The first formulation contained edible glycerin as co-surfactant and the second formulation contained Span 80 as a mixed surfactant. The results of characterization showed that the mean droplet size of drug-free samples was in the range of 16.64-64.62nm with a PDI value of |
| Databáze: | OpenAIRE |
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