Effectiveness of supervised, intermittent therapy for tuberculosis in HIV-infected patients
| Autor: | David Stanton, C. Chaulk, Karla Alwood, Richard E. Chaisson, Jeanne C. Keruly, Kristina Moore-Rice |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis AIDS-Related Opportunistic Infections Immunology Antitubercular Agents White People Acquired immunodeficiency syndrome (AIDS) Risk Factors Internal medicine HIV Seropositivity medicine Immunology and Allergy Humans Sida Substance Abuse Intravenous Survival rate Directly Observed Therapy Probability Retrospective Studies Acquired Immunodeficiency Syndrome Medically Uninsured biology business.industry Medicaid Age Factors virus diseases Retrospective cohort study medicine.disease biology.organism_classification United States CD4 Lymphocyte Count Black or African American Survival Rate Infectious Diseases Treatment Outcome Female Viral disease business |
| Zdroj: | AIDS (London, England). 8(8) |
| ISSN: | 0269-9370 |
| Popis: | To evaluate the effectiveness of supervised therapy for tuberculosis (TB) in patients with HIV infection.Retrospective, chart review.Patients with TB and HIV infection.Urban, public TB clinic.A total of 107 patients with TB and HIV infection were studied. Most were men (78%), African American (91%), uninsured or on Medicaid (88%), and 67% were injecting drug users. TB was diagnosed before AIDS in 31% of subjects, at the time of AIDS in 32%, and after AIDS in 37%. Clinical features varied by stage of HIV disease. Sixteen patients received no therapy and died before TB was diagnosed, 10 died during the first 8 weeks of treatment. Seventy-eight patients received8 weeks therapy, of whom 48 (62%) were given directly observed therapy twice weekly and 30 (38%) received self-administered daily therapy. Patients who received directly observed therapy were more likely to complete 6 months of therapy (96 versus 76%, P = 0.02) and more likely to survive after therapy ended (85 versus 57%, P = 0.01). By logistic regression, directly observed therapy, AIDS diagnosed before TB, and age were significantly associated with survival outcome.Directly observed therapy for TB in patients with HIV infection is highly effective and associated with better adherence to therapy and survival. |
| Databáze: | OpenAIRE |
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