Cerebrospinal fluid biomarkers in Parkinson's disease with freezing of gait: an exploratory analysis
| Autor: | J.C. Howell, J.L. McKay, Jaime M. Hatcher-Martin, W.T. Hu, A F Pybus, Felicia C. Goldstein, L Wood, Stewart A. Factor, Barbara Sommerfeld |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease genetic structures business.industry Disease Exploratory analysis medicine.disease Gastroenterology Gait Article Cellular and Molecular Neuroscience Cerebrospinal fluid Neurology Internal medicine Biomarker (medicine) Medicine Population study In patient Neurology. Diseases of the nervous system Neurology (clinical) RC346-429 business |
| Zdroj: | NPJ Parkinson's Disease npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021) |
| ISSN: | 2373-8057 |
| Popis: | We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer’s disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P |
| Databáze: | OpenAIRE |
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