| Autor: |
Rincón, Yuliet A., Siless, Gastón E., Amado, Lucía Daniela, Dansey, María Virginia, Grassi, Emanuel, Schenone, Nahuel, Cabrera, Gabriela M. |
| Rok vydání: |
2020 |
| DOI: |
10.6084/m9.figshare.12154518.v1 |
| Popis: |
Five new lanostanoid triterpenes were isolated from the extract of R. microporus. Three of the metabolites (1–3) present a Δ8,9 skeleton with an uncommon keto functionality at C–1. Another compound (4) has an unprecedented rearranged skeleton in which methyl-19 was transposed to C–1, with conjugated double bonds at Δ1–10 and Δ8–9. All of the compounds have hydroxylated or furane-cyclized side-chains. The structures were elucidated by spectroscopic methods, and the absolute configuration of the hydroxyl-bearing carbon in the side chain of compound 5 was established in silico. The metabolites were evaluated for their antifungal activity and the bioactivity as agonist/antagonists of the liver X receptors (LXRs). Compound 4 presents antifungal activity and compounds 3 and 5 are the agonists of LXRs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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