Pharmacological characterization of 5-hydroxytryptamine-induced excitation of afferent cervical vagus nerve in anaesthetized rats
| Autor: | Mitsuhiro Yoshioka, Toshiya Ikeda, Hiroko Togashi, Masaru Minami, Masayuki Abe, Hideya Saito |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Agonist Serotonin medicine.medical_specialty Ketanserin medicine.drug_class Biology Internal medicine medicine Animals Neurons Afferent Receptor 5-HT receptor Pharmacology Imidazoles Rats Inbred Strains Vagus Nerve musculoskeletal system Receptor antagonist Ondansetron Sensory neuron Rats Vagus nerve medicine.anatomical_structure Endocrinology nervous system Receptors Serotonin Excitatory postsynaptic potential Serotonin Antagonists Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 106:544-549 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1992.tb14372.x |
| Popis: | 1. An excitatory response to 5-hydroxytryptamine (5-HT) was measured from the afferent vagus nerve of anaesthetized rats. Measurements were determined by an extracellular recording from the whole nerve. 2. Intravenous bolus injection of 5-HT (1.56-100 micrograms kg-1) evoked a dose-dependent excitation of afferent vagus nerve activity. This response was blocked not only by a selective 5-HT3 receptor antagonist, GR38032F (10 and 100 micrograms kg-1), but also by a 5-HT2 receptor antagonist, ketanserin (10 and 100 micrograms kg-1). 3. Both a 5-HT3 receptor agonist, 2-methyl-5-HT (3.12-100 micrograms kg-1), and a 5-HT2 receptor agonist, alpha-methyl-5-HT (3.12-50 micrograms kg-1), produced a dose-dependent excitation of afferent vagus nerve activity. These excitatory effects were antagonized by GR38032F (10 micrograms kg-1) and ketanserin (10 micrograms kg-1), respectively. 4. A 5-HT1 like receptor agonist, 5-carboxamidotryptamine (50 micrograms kg-1), and a putative 5-HT4 receptor agonist, 5-methoxytryptamine (100 micrograms kg-1), failed to produce excitatory effects on the afferent vagus nerve. 5. These results suggest that the 5-HT-induced excitatory response of the afferent vagus nerve might be mediated not only via 5-HT3 receptors but also via 5-HT2 receptors in anaesthetized rats. It is unlikely, however, that either 5-HT1-like or putative 5-HT4 receptors are involved in the excitatory response of the afferent vagus nerve to 5-HT. |
| Databáze: | OpenAIRE |
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