Latest developments in precancerous lesions of hepatocellular carcinoma
| Autor: | Xiao-Jun Niu, Zhao-Shan Niu, Jing Zhao, Wen-Hong Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Frontier 03 medical and health sciences 0302 clinical medicine Risk Factors Molecular genetics Biomarkers Tumor Animals Humans Medicine Early Hepatocellular Carcinoma Pathological business.industry Large cell Liver Neoplasms Gastroenterology General Medicine Hepatitis B Cell Transformation Viral Prognosis medicine.disease digestive system diseases Cell Transformation Neoplastic Nodular lesions 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology business Precancerous Conditions |
| Zdroj: | World Journal of Gastroenterology. 22:3305-3314 |
| ISSN: | 1007-9327 |
| Popis: | Hepatocarcinogenesis in human chronic liver diseases is a multi-step process in which hepatic precancerous lesions progress into early hepatocellular carcinoma (HCC) and progressed HCC, and the close surveillance and treatment of these lesions will help improve the survival rates of patients with HCC. The rapid development and extensive application of imaging technology have facilitated the discovery of nodular lesions of ambiguous significance, such as dysplastic nodules. Further investigations showed that these nodules may be hepatic precancerous lesions, and they often appear in patients with liver cirrhosis. Although the morphology of these nodules is not sufficient to support a diagnosis of malignant tumor, these nodules are closely correlated with the occurrence of HCC, as indicated by long-term follow-up studies. In recent years, the rapid development and wide application of pathology, molecular genetics and imaging technology have elucidated the characteristics of precancerous lesions. Based on our extensive review of the relevant literature, this article focuses on evidence indicating that high-grade dysplastic nodules are more likely to transform into HCC than low-grade dysplastic nodules based on clinical, pathological, molecular genetic and radiological assessments. In addition, evidence supporting the precancerous nature of large cell change in hepatitis B virus-related HCC is discussed. |
| Databáze: | OpenAIRE |
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