Surveillance of HIV type 1 drug resistance among naive patients from Venezuela
| Autor: | Bernard Masquelier, Patricia Pinson, Wilmary Quijada, Mario Comegna, Erika Castro, Valérie Jauvin, Hervé Fleury, Julio Castillo |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Genotype medicine.medical_treatment Immunology Human immunodeficiency virus (HIV) HIV Infections Drug resistance medicine.disease_cause Virus Therapy naive Young Adult HIV Protease Virology Drug Resistance Viral medicine Prevalence Humans Recombination Genetic Protease biology business.industry virus diseases Genetic Variation Middle Aged biology.organism_classification Venezuela Reverse transcriptase HIV Reverse Transcriptase CD4 Lymphocyte Count Infectious Diseases Lentivirus Mutation HIV-1 Female business |
| Zdroj: | AIDS Research and Human Retroviruses, vol. 25, no. 12, pp. 1329-1333 |
| ISSN: | 1931-8405 |
| Popis: | We have studied 65 HIV-1-infected untreated patients recruited in Caracas, Venezuela with TCD4 counts > or =350/microl. The reverse transcriptase and protease sequences of the virus were sequenced, aligned with reference HIV-1 group M strains, and analyzed for drug resistance mutations. Most of the viruses were subtype B genotype in both the protease and RT genomic regions. Five of the 62 virus isolates successfully amplified showed evidence of recombination between protease and RT, with their protease region being non-B while their RT region was derived from subtype B. Four strains were found bearing resistance mutations either to NRTIs, NNRTIs, or PIs. The prevalence of HIV-1 isolates bearing resistance mutations was therefore above the 5% threshold of WHO. |
| Databáze: | OpenAIRE |
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