Combination rapid-acting nicotine mouth spray and nicotine patch therapy in smoking cessation
| Autor: | Julian Crane, Brent Caldwell, Simon J. Adamson |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Nicotine Time Factors Adolescent Nicotine patch medicine.medical_treatment Population Placebo Administration Cutaneous law.invention Young Adult Randomized controlled trial Double-Blind Method law Medicine Humans education Nicotine replacement Aged education.field_of_study business.industry Smoking Public Health Environmental and Occupational Health Middle Aged Nicotine replacement therapy Tobacco Use Cessation Devices Anesthesia Smoking cessation Drug Therapy Combination Female Smoking Cessation business medicine.drug New Zealand |
| Zdroj: | Nicotinetobacco research : official journal of the Society for Research on Nicotine and Tobacco. 16(10) |
| ISSN: | 1469-994X |
| Popis: | Introduction Improved smoking cessation rates are urgently required if New Zealand is to reach its target of a smokefree nation by 2025, during which some 600,000 smokers will need to quit. Nicotine replacement therapy remains a core part of the pharmacological approach to smoking cessation. Oral nicotine solutions with rapid onset have recently become available. We have examined the effect of a nicotine spray and a nicotine patch on smoking cessation for 12 months. Methods We enrolled potential participants-smokers wanting to quit aged 18-70 years, who smoked ≥9 cigarettes per day-with Fagerstrom Test of Nicotine Dependence score ≥3 in a double-blind trial in 3 trial sites. Smokers were randomized to a nicotine or placebo spray for 6 months, and all received nicotine patches daily for 5 months. They were followed at regular intervals for 12 months. Results A total of 1,423 subjects were randomized to nicotine oral spray (1mg of nicotine free base per spray) plus nicotine patch or a placebo spray and nicotine patch. The nicotine mouth spray plus nicotine patch showed significant improvements in prolonged abstinence for all measures to 6 months (7 consecutive days at each visit for 6 months: 15.5% vs. 10.6%; p = .006) for the combination versus placebo and nicotine patch. Thereafter, the differences were not significant. Conclusions The addition of a nicotine mouth spray to a nicotine replacement patch in a population of smokers receiving a low level of behavioral support improved early quitting, but the effects were not sustained. |
| Databáze: | OpenAIRE |
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