Evaluation of the iron status of the newborn by soluble transferrin receptors in serum
| Autor: | Wim Baerts, Jim van Eyck, Henk G. van Eijk, E. P. A. Kuiper-Kramer, Reinout Bakker, Jan van Raan |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty Birth weight Iron Clinical Biochemistry Transferrin receptor Gestational Age Sensitivity and Specificity Reference Values Internal medicine Receptors Transferrin medicine Birth Weight Humans chemistry.chemical_classification Asphyxia Neonatorum biology medicine.diagnostic_test Anemia Iron-Deficiency Biochemistry (medical) Infant Newborn Gestational age General Medicine Metabolism Iron deficiency medicine.disease Ferritin Endocrinology chemistry Solubility Transferrin biology.protein Serum iron |
| Zdroj: | Clinical chemistry and laboratory medicine. 36(1) |
| ISSN: | 1434-6621 |
| Popis: | The concentration of soluble transferrin receptors in serum has proven to be a reliable predictor of iron status in adults. Its high sensitivity for iron deficiency combined with a small sample size (10 μl) makes it an interesting parameter for the assessment of iron stores in newborn infants.In the present study we investigated the usefulness of the concentration of soluble transferrin receptors in serum in the assessment of iron metabolism in the newborn. Infants born after an uncomplicated labour were compared to infants in the intensive care unit. The concentration of soluble transferrin receptors in serum was found to be elevated compared to normal adults and independently of iron metabolism. The concentration of soluble transferrin receptors did not correlate with serum iron and ferritin concentrations. In contrast to what was found in other studies, no relationship could be demonstrated between soluble transferrin receptors and birth weight or gestational age. The results of this study have shown that care has to be taken in the interpretation of the concentration of soluble transferrin receptors in serum in newborn infants. It seems to be a parameter which is independent of iron metabolism at least during the first days of life. |
| Databáze: | OpenAIRE |
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