Regulation of Cell Death in the Lymphoid System by Bcl-2 Family Proteins

Autor:	Iva Ivanovska, J. Marie Hardwick, David A. Hildeman, Heidi L. Galonek
Rok vydání:	2003
Předmět:	Programmed cell death Cell growth Lymphocyte Bcl-2 family Cell Apoptosis Hematology General Medicine Biology Cell fate determination medicine.disease Cell biology Lymphoma medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 medicine Animals Humans Lymphocytes
Zdroj:	Acta Haematologica. 111:42-55
ISSN:	1421-9662 0001-5792
Popis:	Programmed cell death is an ordered process that is essential for the normal development and homeostasis of an organism. Dysregulation of this programmed pathway, resulting in either excess cell numbers or unscheduled cell death, underlies a number of disease states. Bcl-2 family proteins play a key role in regulating cell death and survival, and a number of studies have demonstrated their role as important regulators of cell fate in the lymphoid system. Mice that are genetically deficient or overexpress various Bcl-2 family proteins have provided important clues regarding their roles in lymphocyte development, progression of lymphoid tumors and analogous human disorders. In addition, lymphotropic viruses may trigger cell proliferation and inhibit cell death with the help of their own Bcl-2 homologues. Comparing the shared and distinct functions of viral and cellular Bcl-2-related proteins yields new insight into their fundamental mechanisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2548d576829923e7d575bf49ead81fca https://doi.org/10.1159/000074485 Zobrazit plný text záznamu