Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach
| Autor: | Zsofia Nemoda, Gabriella Balogh, Eszter Dömötör, Anna Szekely, Boglarka Schilling, Zsuzsa Halmai, Maria Sasvari-Szekely, Andrea Sarosi, Krisztina Hejjas, Gabor Faludi |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Oncology Candidate gene medicine.medical_specialty Genotype Anxiety Hospital Anxiety and Depression Scale Young Adult Cellular and Molecular Neuroscience Gene Frequency Polymorphism (computer science) Internal medicine medicine Humans Bipolar disorder Alleles Genetics (clinical) Depression (differential diagnoses) Aged Polymorphism Genetic Depression Receptors Purinergic P2 business.industry Middle Aged medicine.disease Psychiatry and Mental health Case-Control Studies Major depressive disorder Female Receptors Purinergic P2X7 medicine.symptom business |
| Zdroj: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :295-299 |
| ISSN: | 1552-485X 1552-4841 |
| DOI: | 10.1002/ajmg.b.30799 |
| Popis: | The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BPD). The proposed risk allele (G-allele) of the rs2230912 polymorphism results in an amino acid change at the 460th position, marking this genetic variation a possibly functional one. Here we present a case–control analysis of 171 patients diagnosed with MDD or BPD and 178 controls, as well as a dimensional approach using the Hospital Anxiety and Depression Scale (HADS) for studying the Gln460Arg polymorphism of the P2RX7 gene as a genetic risk factor in depression. While case–control analysis did not show significant difference between the groups, a significant association was found between the P2RX7 polymorphism and the HADS scales in the clinical group (MANOVA P = 0.001). Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P |
| Databáze: | OpenAIRE |
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