Pediatric renal cell carcinoma
| Autor: | Justin E. Sausville, David J. Hernandez, John P. Gearhart, Pedram Argani |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Oncology
medicine.medical_specialty Urology medicine.medical_treatment TFE3 urologic and male genital diseases Translocation Genetic Renal neoplasm Renal cell carcinoma Internal medicine medicine Carcinoma Humans Pediatric Renal Cell Carcinoma Child Carcinoma Renal Cell Lymph node Chemotherapy business.industry Neoplasms Second Primary medicine.disease Kidney Neoplasms female genital diseases and pregnancy complications Dissection medicine.anatomical_structure Pediatrics Perinatology and Child Health business |
| Zdroj: | Journal of Pediatric Urology. 5:308-314 |
| ISSN: | 1477-5131 |
| DOI: | 10.1016/j.jpurol.2009.04.007 |
| Popis: | Renal cell carcinoma (RCC) comprises about 5% of pediatric renal neoplasms. It has been recognized as a second malignancy in multiple reports. It is generally symptomatic at diagnosis, and most children with RCC present with more locally advanced disease than do adults. Contemporary investigation of pediatric RCC has demonstrated that a large percentage of these tumors bear cytogenetic translocations involving the MiT family of transcription factors. Surgical therapy for these children resembles operative intervention for adult RCC, though debate continues about the precise role of lymph node dissection. There are no adequately powered studies to support conclusions about adjuvant or neoadjuvant chemotherapy for children with RCC. This may be ameliorated by a multi-institutional protocol which is enrolling patients. |
| Databáze: | OpenAIRE |
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