Hyperdirect insula-basal-ganglia pathway and adult-like maturity of global brain responses predict inhibitory control in children
| Autor: | Weidong Cai, Vinod Menon, Katherine Duberg, Travis Bradley, Rachel Rehert, Victor G. Carrion, Aarthi Padmanabhan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Adolescent Databases Factual media_common.quotation_subject Science General Physics and Astronomy Biology General Biochemistry Genetics and Molecular Biology Basal Ganglia Article 03 medical and health sciences Young Adult 0302 clinical medicine Subthalamic Nucleus Inhibitory control Basal ganglia Human behaviour Cognitive development Reaction Time Humans Young adult lcsh:Science Child media_common Cerebral Cortex Multidisciplinary Brain Cognitive neuroscience General Chemistry Magnetic Resonance Imaging Maturity (psychological) Subthalamic nucleus Inhibition Psychological 030104 developmental biology lcsh:Q Insula Neuroscience 030217 neurology & neurosurgery Right anterior |
| Zdroj: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| ISSN: | 2041-1723 |
| Popis: | Inhibitory control is fundamental to children’s self-regulation and cognitive development. Here we investigate cortical-basal ganglia pathways underlying inhibitory control in children and their adult-like maturity. We first conduct a comprehensive meta-analysis of extant neurodevelopmental studies of inhibitory control and highlight important gaps in the literature. Second, we examine cortical-basal ganglia activation during inhibitory control in children ages 9–12 and demonstrate the formation of an adult-like inhibitory control network by late childhood. Third, we develop a neural maturation index (NMI), which assesses the similarity of brain activation patterns between children and adults, and demonstrate that higher NMI in children predicts better inhibitory control. Fourth, we show that activity in the subthalamic nucleus and its effective connectivity with the right anterior insula predicts children’s inhibitory control. Fifth, we replicate our findings across multiple cohorts. Our findings provide insights into cortical-basal ganglia circuits and global brain organization underlying the development of inhibitory control. Late childhood is an important period for the development of inhibitory control underlying self-regulation and impulse control behavior. Here, the authors identify brain mechanisms and functional cortical-basal ganglia circuits that predict inhibitory control in children. |
| Databáze: | OpenAIRE |
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