Fatal Herpes Simplex Hepatitis in a Newborn Infant
| Autor: | Parker R. Beamer, Stanley Hellerstein, Robert A. McDougal |
|---|---|
| Rok vydání: | 1954 |
| Předmět: |
Herpes simplex hepatitis
Necrosis business.industry Herpes Simplex Infections Infant Newborn Infant Herpes Simplex Herpesviridae Infections General Medicine Hemorrhagic Disorders medicine.disease_cause medicine.disease Infant newborn Virology Infant Newborn Diseases Virus Hepatitis Herpes simplex virus medicine Humans medicine.symptom Child business Clinical syndrome Encephalitis |
| Zdroj: | American Journal of Clinical Pathology. 24:1250-1258 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/24.11.1250 |
| Popis: | The infective nature of certain herpetic lesions was demonstrated about 50 years ago, and, subsequently, many studies established the presence of a filterable dermotropic agent in vesicular, often ulcerated, lesions of the skin and mucous membranes of the mouth, lips, eyes and genitalia. This agent is designated by 1 of 3 terms, viz., herpes, herpes febrilis or herpes simplex virus, and should not be confused with herpes zoster, which is distinctly different. Studies with experimental animals indicate that various strains of herpes simplex virus are endowed with neurotropic, or viscerotropic properties, or both, in addition to the dermotropic quality, and the preference for certain tissues or organs in a given instance seems to depend on environmental factors in the host. For example, a strain that is predominantly neurotropic in one type of host may show little or no neurotropic tendency in another. Fatal herpetic infections of human viscera, including the brain, have been described by several investigators, 9i "• 13,21_23 but studies to prove the identity of the vims were performed in relatively few instances.' Two of the strains of herpes virus were isolated from patients with encephalitis,' and the other 2 were from infants with widespread necrosis of the liver, and other tissues as well. The purpose of this paper is to present the findings in a newborn infant whose clinical syndrome was that of fatal hemorrhagic diathesis. Intranuclear inclusion bodies, morphologically characteristic of those occurring in known herpes simplex infections, were observed in the widespread lesions of the liver, and a virus identical with herpes simplex was isolated from the lesions.* |
| Databáze: | OpenAIRE |
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