Isolation of Lagos Bat Virus from Water Mongoose
| Autor: | Louis Hendrik Nel, Wanda Markotter, Charles E. Rupprecht, Jenny Randles, Claude T. Sabeta, Ivan V. Kuzmin, Alexander I. Wandeler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
animal structures
Herpestidae viruses Mokola virus lcsh:Medicine rabies phylogeny DNA Mitochondrial Virus lcsh:Infectious and parasitic diseases South Africa Mice lyssaviruses Rhabdoviridae Infections biology.animal rabies-related viruses medicine Lagos bat virus Animals lcsh:RC109-216 Fluorescent Antibody Technique Indirect Antigens Viral Lyssavirus nucleoprotein Mice Inbred ICR Virulence biology Reverse Transcriptase Polymerase Chain Reaction Cytochrome b Research pathogenesis Atilax paludinosus lcsh:R Sequence Analysis DNA Cytochromes b Nucleocapsid Proteins medicine.disease biology.organism_classification Virology Mongoose mongoose cytochrome b RNA Viral Biological Assay Rabies |
| Zdroj: | Emerging Infectious Diseases, Vol 12, Iss 12, Pp 1913-1918 (2006) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | One-sentence summary for table of contents: Lagos bat virus from water mongoose showed strong sequence homology with other Lagos bat virus isolates from South Africa. A genotype 2 lyssavirus, Lagos bat virus (LBV), was isolated from a terrestrial wildlife species (water mongoose) in August 2004 in the Durban area of the KwaZulu-Natal Province of South Africa. The virus isolate was confirmed as LBV by antigenic and genetic characterization, and the mongoose was identified as Atilax paludinosus by mitochondrial cytochrome b sequence analysis. Phylogenetic analysis demonstrated sequence homology with previous LBV isolates from South African bats. Studies performed in mice indicated that the peripheral pathogenicity of LBV had been underestimated in previous studies. Surveillance strategies for LBV in Africa must be improved to better understand the epidemiology of this virus and to make informed decisions on future vaccine strategies because evidence is insufficent that current rabies vaccines provide protection against LBV. |
| Databáze: | OpenAIRE |
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