Salivary Duct Carcinoma With Rhabdoid Features-No or Aberrant Expression of E-cadherin and Genetic Changes in CDH1: Immunohistochemical and Genetic Analyses of 17 Cases
| Autor: | Keiko Ishino, Hidetaka Yamada, Tomoyuki Ohuchi, Satoshi Baba, Makoto Suzuki, Haruhiko Sugimura, Chinatsu Tsuchiya, Matsuyoshi Maeda, Hidetaka Yamamoto, Koji Yamanegi, Hiroshi Inagaki, Tomohiro Iwasaki, Kimihide Kusafuka |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Nonsense mutation Lobular carcinoma DNA Mutational Analysis Adenoma Pleomorphic Vimentin Breast Neoplasms Pathology and Forensic Medicine Salivary duct carcinoma CDH1 03 medical and health sciences 0302 clinical medicine Antigens CD medicine Biomarkers Tumor Missense mutation Humans In Situ Hybridization Fluorescence Aged Aged 80 and over biology Cadherin Carcinoma Middle Aged medicine.disease Cadherins Salivary Gland Neoplasms Immunohistochemistry Carcinoma Lobular 030104 developmental biology Carcinoma ex pleomorphic adenoma 030220 oncology & carcinogenesis Mutation biology.protein Surgery Female Anatomy |
| Zdroj: | The American journal of surgical pathology. 45(4) |
| ISSN: | 1532-0979 |
| Popis: | Salivary duct carcinoma is a relatively uncommon malignancy of the salivary glands; however, it frequently occurs as a carcinomatous component of carcinoma ex pleomorphic adenoma. We previously reported salivary duct carcinoma with rhabdoid features (SDCRF) as an extremely rare subtype of salivary duct carcinoma, and that it occurred as a salivary counterpart of pleomorphic lobular carcinoma of the breast (PLCB). We collected new cases of SDCRF for this study, in which we examined a total of 17 cases immunohistochemically and genetically. As it is known that PLCB exhibits loss of or aberrant E-cadherin expression and carries nonsense/missense mutations in or deletion of the CDH1 gene, we examined the CDH1 gene status of our SDCRF cases. All of the examined SDCRF cases involved the diffuse proliferation of large ovoid cells with eosinophilic cytoplasm and eccentric nuclei, which displayed reduced cell-cell adhesion. Most cases were positive for pan-cytokeratin, androgen receptor, gross cystic disease fluid protein-15, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, and WI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4, whereas they were negative for vimentin. No and decreased/cytoplasmic E-cadherin expression was observed in 11 and 4 of 17 cases, respectively, whereas no and decreased/cytoplasmic β-catenin expression were observed in 10 and 5 of 17 cases, respectively. Among the 11 cases that could be genetically analyzed, a nonsense mutation (1 case), missense mutations (6 cases), and insertions (1 case) were detected in the CDH1 gene. In conclusion, we propose that SDCRF is the salivary counterpart of PLCB due to its morphology and immunophenotype, and the genetic status of CDH1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|