Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols—A proof-of-concept study
| Autor: | Albin Hermetter, Chris A. Tarling, Stephen G. Withers, Andreas Steiner, Arnold E. Stütz, Tanja M. Wrodnigg, Hannes Schmidinger |
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| Rok vydání: | 2008 |
| Předmět: |
Magnetic Resonance Spectroscopy
Glycoside Hydrolases Clinical Biochemistry Iminosugar Pharmaceutical Science Biochemistry chemistry.chemical_compound Drug Discovery Glycoside hydrolase Enzyme Inhibitors Molecular Biology β glucosidase chemistry.chemical_classification Molecular Structure Chemistry Organic Chemistry Microarray Analysis Imino Sugars Enzyme DNA glycosylase Silicon chip Molecular Medicine DNA microarray Polyamine Rhizobium |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 18:1922-1925 |
| ISSN: | 0960-894X |
| Popis: | Three typical glycosidase-inhibiting iminoalditols were attached to a polyamine surface displayed on a silicon chip. Exposure to a representative beta-glucosidase revealed selective binding events reflecting the different structural features of the inhibitors probed in this study. This provides a proof-of-concept for the successful exploitation of microarrays of typical reversible glycosidase inhibitors of the iminosugar family. |
| Databáze: | OpenAIRE |
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