IL-1 receptor antagonist gene polymorphism in recurrent spontaneous abortion
| Autor: | Mikko Hurme, Tarja Laitinen, Helena Kivelä, Anja Tiilikainen, Jari Karhukorpi |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Abortion Habitual medicine.medical_specialty Genotype Sialoglycoproteins Immunology Biology Gene Frequency Pregnancy Internal medicine Odds Ratio medicine Humans Immunology and Allergy Allele Allele frequency Finland Polymorphism Genetic Base Sequence Case-control study Obstetrics and Gynecology Interleukin DNA Odds ratio Middle Aged Interleukin 1 Receptor Antagonist Protein Endocrinology Interleukin 1 receptor antagonist Reproductive Medicine Case-Control Studies Female Gene polymorphism Interleukin-1 Signal Transduction |
| Zdroj: | Journal of Reproductive Immunology. 58:61-67 |
| ISSN: | 0165-0378 |
| Popis: | Genetic factors may contribute to the development of an aberrant pro-inflammatory immune response during pregnancy, thereby increasing the risk of some pregnancy-related pathologies such as recurrent spontaneous abortion (RSA). Interleukin 1 receptor antagonist is an important anti-inflammatory molecule encoded by the IL1RN gene, in which an intronic polymorphism has been described. Even though the molecular genetic mechanisms are not understood, this non-coding polymorphism, and especially IL1RN*2, has been associated with several chronic inflammatory and autoimmune diseases. IL1RN*2 is also associated with increased activity of IL-1β, which is an important pro-inflammatory cytokine. We investigated the genetic variants of IL1RN in 37 Finnish women with RSA and 800 randomly selected Finnish blood donors. The women with RSA showed a significantly increased frequency of genotypes bearing the rare allele IL1RN*3 compared to the blood donors (10.8 vs 2.1%, odds ratio 5.6, 95% CI: 1.5–19.0, P =0.006). Our results suggest that IL1RN polymorphisms may predispose to RSA in a small subgroup of patients. |
| Databáze: | OpenAIRE |
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