Mutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative
| Autor: | Rodney A. Barton, Sujan Sigh, Robert E. Lyle, Sharon S. Yoder, Myron K. Jacobson |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Salmonella typhimurium
endocrine system Cancer Research Salmonella Nitrosamines Stereochemistry Drug Evaluation Preclinical Alpha (ethology) Mutagen In Vitro Techniques medicine.disease_cause Toxicology chemistry.chemical_compound Biotransformation Benzyl Compounds medicine Animals Carcinogen fungi food and beverages Rats Oncology chemistry Nitrosamine Microsomes Liver Microsome NADP Derivative (chemistry) Mutagens |
| Zdroj: | Cancer Letters. 6:83-87 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(79)80005-1 |
| Popis: | The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence of a metabolic activation system while (II) was highly mutagenic when tested directly. This is the first report on the conversion of a non-mutagenic N-nitrosamine to a mutagen by the formation of an alpha-acetoxy derivative. |
| Databáze: | OpenAIRE |
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