Genetic diversity of bat orthohepadnaviruses in China and a proposed new nomenclature
| Autor: | Jianmin Wu, Bo Deng, Biao He, Liu Jinfeng, Changchun Tu, Tingsong Hu, Ling'en Yang, Shaomin Qin, Fuqiang Zhang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) China Range (biology) 030231 tropical medicine Population Genome Viral medicine.disease_cause Microbiology Genome Article Genetic diversity 03 medical and health sciences 0302 clinical medicine Orthohepadnavirus Chiroptera Bats Genetics medicine Animals education Molecular Biology Nomenclature Phylogeny Ecology Evolution Behavior and Systematics Hepatitis B virus education.field_of_study biology Phylogenetic tree Genetic Variation Hepadnaviridae Infections biology.organism_classification 030104 developmental biology Infectious Diseases Evolutionary biology Hepatitis Viral Animal |
| Zdroj: | Infection, Genetics and Evolution |
| ISSN: | 1567-1348 |
| DOI: | 10.1016/j.meegid.2018.05.024 |
| Popis: | The orthohepadnaviruses, which include the major human pathogen hepatitis B virus, exist in a wide range of hosts. Since 2013, a large group of orthohepadnaviruses has been identified in bats worldwide and classified as 4 species within the genus Orthohepadnavirus. To further investigate orthohepadnaviruses in the Chinese bat population, 554 archived bat samples from 20 colonies covering 3 southern provinces were screened with results showing that 9 (1.6%) were positive. A systematic phylogenetic analysis has indicated the need for a new nomenclature for bat hepatitis B virus-like viruses: BtHBV, with the addition of 3 new species, one being divided into 6 genotypes. Viruses identified here shared 9.0–19.2% full genome divergence and classified into 3 different genotypes. This study illustrates the genetic diversity of orthohepadnaviruses in the Chinese bat population, and emphasizes need for further investigation of their public health significance. Highlights • Three new orthohepadnaviral lineages were identified in Chinese bats. • A new nomenclature was proposed for bat hepatitis B virus-like viruses. • This study indicates genetic diversity of orthohepadnaviruses in Chinese bats. |
| Databáze: | OpenAIRE |
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