Hemodynamic and autonomic effects of intravenous saterinone in patients with chronic heart failure
| Autor: | K. Stolzenburg, Jan-Leendert P. Brouwer, A. Lahiri, R. B. Van Dijk, V. Mitrovic, D. J. Van Veldhuisen, Kong I. Lie, Balázs M. Szabó |
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| Přispěvatelé: | Cardiovascular Centre (CVC) |
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Phosphodiesterase Inhibitors Pyridones Hemodynamics Autonomic Nervous System Plasma renin activity DISEASE Piperazines Electrocardiography hemodynamic effects Double-Blind Method Heart Rate Internal medicine Heart rate medicine Heart rate variability Humans RATE-VARIABILITY PARAMETERS Aged Pharmacology Heart Failure Neurotransmitter Agents business.industry Middle Aged medicine.disease Autonomic nervous system Endocrinology medicine.anatomical_structure Blood pressure Heart failure Injections Intravenous Vascular resistance Cardiology Female Cardiology and Cardiovascular Medicine business autonomic effects saterinone |
| Zdroj: | Journal of Cardiovascular Pharmacology, 29(5), 618-623 |
| ISSN: | 0160-2446 |
| Popis: | In this study, the hemodynamic and neurohumoral/autonomic effects of intravenous saterinone (a selective phosphodiesterase type III inhibitor, with additional alpha(1)-blocking properties) were evaluated. In a double-blind, placebo-controlled design, 36 patients with moderate to severe heart failure were studied (saterinone, n = 24; placebo, n = 12). Invasive hemodynamic measurements, by using right-heart catheterization, were performed, as well as measurement of plasma neurohormones and analysis of heart rate variability (HRV), to study drug influences on neurohumoral activation and autonomic tone. Systemic vascular resistance significantly decreased during saterinone infusion, accompanied by a decrease in systemic blood pressure (both p values |
| Databáze: | OpenAIRE |
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