Peripheral polymorphonuclear leukocyte priming contributes to oxidative stress in early pregnancy
| Autor: | S. Sela, G. Dourleshter, N. Khatib, V. Fait, A. Perri, Rene Tendler, H. Kreutzer, Oleg Shnaider, Ella Ophir, Jacob Bornstein |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Neutrophils Primage Granulocyte medicine.disease_cause Blood cell 03 medical and health sciences chemistry.chemical_compound Leukocyte Count 0302 clinical medicine Pregnancy Superoxides Internal medicine medicine Humans Prospective Studies 030219 obstetrics & reproductive medicine Superoxide business.industry Obstetrics and Gynecology Venous blood medicine.disease Alkaline Phosphatase Oxidative Stress Pregnancy Trimester First medicine.anatomical_structure Endocrinology chemistry Alkaline phosphatase Female business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of the Society for Gynecologic Investigation. 12(1) |
| ISSN: | 1071-5576 |
| Popis: | The cause of elevated blood leukocyte count in pregnancy is unknown. We hypothesized that priming of peripheral polymorphonuclear leukocytes (PMNL) caused this elevation. Eleven women in the first trimester of pregnancy were included in this prospective study. Peripheral venous blood was drawn twice from each woman, before and after a medical abortion (pregnant and nonpregnant, respectively). Complete blood cell count, plasma alkaline phosphatase (ALP), and rate of superoxide release from separated phobrol 12-myristate-13-acetate (PMA)-stimulated PMNL were determined. The PMNL count in early pregnancy was significantly higher, with a significant increase in the PMNL rate of superoxide release compared to the nonpregnant state. A linear correlation between the rates of superoxide release and PMNL counts before and during pregnancy was found. ALP levels were significantly elevated in early pregnancy. The increased PMNL count is probably a compensatory response to PMNL priming. The increased rate of superoxide release from primed PMNL may contribute to oxidative stress in early pregnancy. |
| Databáze: | OpenAIRE |
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