Toll and Toll-like receptor signalling in development
| Autor: | Istvan Foldi, Niki C Anthoney, Alicia Hidalgo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neural Conduction Context (language use) Cell fate determination Biology Synaptic Transmission 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Humans Molecular Biology Toll-like receptor Innate immune system Toll-Like Receptors NF-kappa B NF-κB Hedgehog signaling pathway 030104 developmental biology Signalling chemistry Toll Synapses biology.protein Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Development. 145 |
| ISSN: | 1477-9129 0950-1991 |
| Popis: | The membrane receptor Toll and the related Toll-like receptors (TLRs) are best known for their universal function in innate immunity. However, Toll/TLRs were initially discovered in a developmental context, and recent studies have revealed that Toll/TLRs carry out previously unanticipated functions in development, regulating cell fate, cell number, neural circuit connectivity and synaptogenesis. Furthermore, knowledge of their molecular mechanisms of action is expanding and has highlighted that Toll/TLRs function beyond the canonical NF-κB pathway to regulate cell-to-cell communication and signalling at the synapse. Here, we provide an overview of Toll/TLR signalling and discuss how this signalling pathway regulates various aspects of development across species. |
| Databáze: | OpenAIRE |
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