Axillary recurrence in breast cancer
Autor: | C.R. Gillis, David J Hole, David B. Kingsmore, W.D. George |
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Rok vydání: | 2005 |
Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Breast cancer Recurrence medicine Carcinoma Humans Sampling (medicine) Registries Pathological Aged Chemotherapy business.industry Incidence Incidence (epidemiology) Carcinoma Ductal Breast General Medicine Middle Aged medicine.disease Surgery Radiation therapy Axilla medicine.anatomical_structure Scotland Oncology Lymphatic Metastasis Female Lymph Nodes business |
Zdroj: | European Journal of Surgical Oncology (EJSO). 31:226-231 |
ISSN: | 0748-7983 |
Popis: | Aim To determine whether axillary recurrence reflects inadequate axillary treatment or adverse pathological features. Methods The case-records were reviewed of 2122 women aged under 75 years, treated for invasive breast cancer during the time-period 1/1/86–31/12/91 in a geographically defined area. Data were abstracted on operations performed, pathological features, post-operative treatments and details of axillary recurrence. The risk of axillary recurrence was examined by pathological, treatment and patient factors. Results Axillary recurrence was more than twice as likely after inadequate compared to adequate treatment of the axilla (adequate staging or axillary radiotherapy or clearance). Delayed treatment of the axilla was not as successful as adequate primary treatment: multiple axillary recurrences were twice as common, one third of which were uncontrolled at time of death. Inadequate surgical treatment was associated with increased rates of recurrence despite endocrine therapy, chemotherapy or radiotherapy. Lymphoedema was twice as common if axillary radiotherapy was combined with any axillary surgical procedure. Conclusions Axillary recurrence is more common in tumours with adverse pathology but may also result from inadequate axillary treatment. In order to minimise axillary recurrence, optimal treatment of the axilla entails adequate staging (sampling of four or more nodes) and treatment (axillary clearance or radiotherapy and endocrine therapy) in all women. |
Databáze: | OpenAIRE |
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