Predicting lung adenocarcinoma prognosis with a novel risk scoring based on platelet-related gene expression
Autor: | Yongsheng Wang, Ying Wang, Jian-Jun Yang, Guoren Zhou, Lei Lei, Hongping Xia, Muhuo Ji, Chengmao Zhou |
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Rok vydání: | 2020 |
Předmět: |
Oncology
Aging medicine.medical_specialty bioinformatics analysis Lung Neoplasms DNA Copy Number Variations Adenocarcinoma of Lung Risk Assessment nomogram Germline mutation Internal medicine medicine Humans Clinical significance Copy-number variation Risk factor platelet Framingham Risk Score business.industry Cell Biology Cell cycle Nomogram TCGA medicine.disease Prognosis lung adenocarcinoma Gene Expression Regulation Neoplastic Survival Rate MicroRNAs Nomograms Mutation Adenocarcinoma business Research Paper |
Zdroj: | Aging (Albany NY) |
ISSN: | 1945-4589 |
Popis: | Lung adenocarcinoma is the most common subtype of non-small cell lung cancer, and platelet receptor-related genes are related to its occurrence and progression. A new prognostic indicator based on platelet receptor-related genes was developed with multivariate COX analysis. Prognostic markers based on platelet-related risk score perform moderately in prognosis prediction. The functional annotation of this risk model in high-risk patients shows that the pathways related to cell cycle, glycolysis and platelet-derived related factors are rich. It is worth noting that somatic mutation analysis shows that TTN and MUC16 have higher mutation burdens in high-risk patients. Moreover, the differential genes of high- and low-risk groups are regulated by copy number variation and miRNA. And we provide a free online nomogram web tool based on clinical factors and the risk score (https://wsxzaq.shinyapps.io/wsxzaq_nomogram/). The score has been verified among three independent external cohorts (GSE13213, GSE68465 and GSE72094), and is still an independent risk factor for lung adenocarcinoma. In addition, among the other 6 cancers, the OS prognosis of high and low-risk groups of PRS is different (P < 0.05). Our research results have screened multiple platelet differential genes with clinical significance and constructed a meaningful prognostic risk score (PRS). |
Databáze: | OpenAIRE |
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