NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel

Autor:	Elena Mironova, Crystal R. Archer, Aleksandr E. Vendrov, Marschall S. Runge, Nageswara R. Madamanchi, William J. Arendshorst, James D. Stockand, Tarek Mohamed Abd El-Aziz
Rok vydání:	2022
Předmět:	Mice Knockout Mice Physiology Angiotensin II Sodium NADPH Oxidase 1 Animals NADPH Oxidases Epithelial Sodium Channels Adaptor Proteins Signal Transducing
Zdroj:	American journal of physiology. Renal physiology. 323(6)
ISSN:	1522-1466
Popis:	Activity of the epithelial Na+ channel (ENaC) in the distal nephron fine-tunes renal Na+ excretion. Angiotensin II (ANG II) has been reported to enhance ENaC activity. Emerging evidence suggests that NADPH oxidase (NOX) signaling plays an important role in the stimulation of ENaC by ANG II in principal cells. The present findings indicate that NOX activator 1/NOX1 signaling mediates ANG II stimulation of ENaC in renal principal cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253428199a3cfbae1ac195c5a07e12a5 https://pubmed.ncbi.nlm.nih.gov/36201326 Zobrazit plný text záznamu