Selective distribution of fibronectin to a tumor-cell line
| Autor: | Koji Munechika, Satoshi Morimoto, Kazumasa Yokoyama, Yosio Kagitani, Yasuo Ueda, Kenji Tanaka |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Tumor cells Iodine Radioisotopes Internal medicine medicine Distribution (pharmacology) Animals Humans Sarcoma Yoshida Serum Albumin chemistry.chemical_classification Chemotherapy biology Albumin Rats Inbred Strains Fibronectins Rats Fibronectin Endocrinology Oncology chemistry Immunology Time course biology.protein Autoradiography Glycoprotein Selective distribution |
| Zdroj: | Cancer letters. 31(3) |
| ISSN: | 0304-3835 |
| Popis: | Distribution of plasma fibronectin in Yoshida sarcoma-bearing rats was studied. Fibronectin from human plasma labelled with 125I was administered intravenously to the tumor bearing-rats. The ratios of specific radioactivity (cpm/g) of the tumor to that of blood or liver increased in the time course after the administration. Consequently, 48 h later, the tumor/blood and the tumor/liver ratios were estimated to be 4.6 and 2.8, respectively. In contrast, the liver/blood ratio did not increase during the experimental period. Similar results were also obtained by the administration of fibronectin from rat plasma. Whole-body autoradiography also suggested such a selective distribution. However, 125I-labelled albumin was not localized in the tumor. |
| Databáze: | OpenAIRE |
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