Thyroid autoantibodies and associated complications during pregnancy
| Autor: | Y D Bakin, M J M Johari, Norasyikin Abd Wahab, M. I. Nor Azlin, Norlaila Mustafa, MA Jamil, N A Kamarudin |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Thyroiditis endocrine system diseases medicine.medical_treatment Gastroenterology Hyperthyroidism Iodide Peroxidase Thyroglobulin Young Adult Hypothyroidism Pre-Eclampsia Thyroid peroxidase Pregnancy Seroepidemiologic Studies Internal medicine medicine Humans Abruptio Placentae Autoantibodies biology business.industry Cesarean Section Thyroid disease Obstetrics and Gynecology Receptors Thyrotropin medicine.disease Anti-thyroid autoantibodies Pregnancy Complications Endocrinology embryonic structures Postpartum thyroiditis biology.protein Female Thyroid function business Immunoglobulins Thyroid-Stimulating |
| Zdroj: | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 30(7) |
| ISSN: | 1364-6893 |
| Popis: | This study was undertaken to determine the presence of thyroid autoantibodies and associated pregnancy complications from 49 pregnant women with thyroid disease. There were 31 (63%) women with Graves' disease (GD) and 18 (37%) with primary hypothyroidism (PHT). A total of 26 (53.1%) women, 19 (61%) with GD and seven (39%) with PHT, had positive antibodies. Six had thyroid peroxidase antibodies (TPO), one with thyroglobulin antibody (TG) and eight had TSH receptor antibodies (TR). Two had a mixture of antibodies involving TG/TPO (one GD vs one PHT), four with TG/TPO/TR (all had GD) and five with TPO/TR (four with GD vs one with PHT). There were associations in women with positive thyroid antibodies and pre-eclampsia (15.4%), abruptio placenta (4%), caesarean deliveries (31%), postpartum thyroiditis (19.2%) and abnormal neonatal thyroid function (15.4%). Women with positive thyroid antibodies in pregnancy need close care during and after pregnancy, as they can develop complications affecting both mother and fetus. |
| Databáze: | OpenAIRE |
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